Flexible intraretinal implants

Development and in vitro validation of flexible intraretinal probes, - Rincón Montes V., Gehlen J., Ingebrandt S., Mokwa W., Walter P., Müller F. and Offenhäusser A., Sci Rep 10, 19836 (2020).

Surface Functionalization of Platinum Electrodes with APTES for Bioelectronic Applications

The coating of neuroelectronic surfaces converts bioincompatible electrodes into biocompatible surfaces and permits a perfect electronic cell-chip coupling. Thus, we obtain a surface modification protocol that facilitates the chemical and biocompatible modification of dielectric oxides and metals of bioelectronics devices in one preparation step.

Surface Plasmon-Enhanced Kinetics of Molecular Switches

Gold nanohole arrays are proposed as transparent and conductive plasmonic material that accelerates visible-light-triggered chemical reactions including molecular switching.

Polymer transistors for cell recordings

High-Aspect-Ratio Nanoelectrodes for Neuronal Recordings

High-Aspect-Ratio Nanoelectrodes Enable Long-Term Recordings of Neuronal Signals with Subthreshold Resolution , - P. Shokoohimehr, B. Cepkenovic, F. Milos, J. Bednár, H. Hassani, V. Maybeck, A. Offenhäusser, Small 2022, 18, 2200053.

Polymer Nanopillars Induce Neuronal Adhesion and Axon Growth

Polymer Nanopillars Induce Increased Paxillin Adhesion Assembly and Promote Axon Growth in Primary Cortical Neurons, -F. Milos, A. Belu, D. Mayer, V. Maybeck, A. Offenhäusser, Adv. Biology 2021, 5, 2000248.

Frequency Mixing Magnetic Detection Setup Employing Permanent Ring Magnets.

In this work, a measurement head for frequency mixing magnetic detection (FMMD) is introduced which involves the utilization of two ring-shaped permanent magnets to generate a static offset magnetic field. A steel cylinder in the ring bores homogenizes the field. Through variation of the distance between the ring magnets and of the thickness of the steel cylinder, the magnitude of the magnetic field at the sample position can be adjusted. Furthermore, the measurement setup is compared to the electromagnet offset module based on measured signals and temperature behavior.

Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

In the paper published in Nature Neuroscience our colleague and researchers at RWTH Aachen University, Cold Spring Harbor Laboratory and other institutes in the United States closely examined the functions of different pyramidal cells, which are commonly found in the human cortex (s. Medical Xpress article for add. information).

Toward the Next Generation of Neural Iontronic Interfaces

Our colleagues Csaba Forro, Simon Musall, Viviana Ricon Montes, Andreas Offenhäusser, Francesca Santoro and other researchers at RWTH Aachen University, published a perspective review paper on the development of neural interfaces.

Validation of transparent and flexible neural implants for simultaneous electrophysiology, functional imaging, and optogenetic

Our IBI-3 colleagues and researchers from other Institutes at Research Center Jülich and at RWTH Aachen University, published an article in the themed collection ‘Emerging Investigators’ in the ‘Journal of Materials Chemistry B’

Single-neuron mechanical perturbation evokes calcium plateaus that excite and modulate the network

In our new Scientific Reports publication Cepkenovic et al describes how small mechanical stimuli applied to a single neuron can have wide reaching and long lasting effects on neuronal network signalling. Piezo channels and gap junctions were implicated in conduction of these calcium based changes in activity. The findings have wide ranging implications from the design of non-invasive ultrasound brain stimulation to interpretation of the gold-standard of measuring neural activity - the patch clamp technique.

An organic brain-inspired platform with neurotransmitter closed-loop control, actuation and reinforcement learning

Our colleagues have published a paper in Materials Horizons /Bruno U., Rana D., Ausilio C., Mariano A., Bettucci O., Musall S., Lubrano C. and Santoro F., Mater. Horiz., 2024, Advance Article, https://doi.org/10.1039/D3MH02202A/ , which was selected as a part of the themed collection: Memristors and Neuromorphic Systems . In this manuscript a brain-inspired closed-loop system has been demonstrated for the accomplishment of motor control and actuation tasks, through a learning process mediated by a neurotransmitter.