Institute of Biological Information Processing (IBI)

Bioelectronics (IBI-3)

Project FEMIC

Dual-modality field effect/magnetic immunosensor chip for label-free biomarker detection

We develop the magnetic readout of the dual-modality immunosensor for detection of multiple biomarkers. By means of the well-established frequency mixing magnetic detection for probing the binding state of magnetic nanoparticles, a contactless readout technique is realized. Magnetic nanoparticles will be used for capturing and separation of target biomarkers from samples, for their concentration on the immunochip surface, and for magnetic detection. We systematically study basic working characteristics (sensitivity, detection limit, specificity, reusability, etc.) of the dual-modality immunochip and compare them with theoretical predictions. The work is expected to have distinct impact bringing field-effect and magnetic detection principle together for possible future diagnostic tools such as point-of-care applications.